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Swedish snus use is associated with mortality: a pooled analysis of eight prospective studies.
- Source :
-
International Journal of Epidemiology . Dec2020, Vol. 49 Issue 6, p2041-2050. 10p. - Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>The health consequences of the use of Swedish snus, including its relationship with mortality, have not been fully established. We investigated the relationship between snus use and all-cause and cause-specific mortality (death due to cardiovascular diseases, cancer diseases and all other reasons, respectively) in a nationwide collaborative pooling project.<bold>Methods: </bold>We followed 169 103 never-smoking men from eight Swedish cohort studies, recruited in 1978-2010. Shared frailty models with random effects at the study level were used in order to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) of mortality associated with snus use.<bold>Results: </bold>Exclusive current snus users had an increased risk of all-cause mortality (aHR 1.28, 95% CI 1.20-1.35), cardiovascular mortality (aHR 1.27, 95% CI 1.15-1.41) and other cause mortality (aHR 1.37, 95% CI 1.24-1.52) compared with never-users of tobacco. The risk of cancer mortality was also increased (aHR 1.12, 95% CI 1.00-1.26). These mortality risks increased with duration of snus use, but not with weekly amount.<bold>Conclusions: </bold>Snus use among men is associated with increased all-cause mortality, cardiovascular mortality, with death from other causes and possibly with increased cancer mortality. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03005771
- Volume :
- 49
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- International Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 148569658
- Full Text :
- https://doi.org/10.1093/ije/dyaa197