Estimation Vitamin D, Calcium and Total Oxidant Status Levels in Colorectal Cancer Patients.

Colorectal cancer (CRC) is one of the most common malignancies of the digestive system worldwide with the incidence has being increased significantly over the past three decades. CRC could present as sporadic (70%), more than half (55%) of all CRCs are attributable to lifestyle factors, including an unhealthy diet. Some studies refer higher circulating vitamin D ( 25(OH)D )was related to a statistically significant, substantially lower colorectal cancer risk, and other studies proposed the total calcium intake was inversely associated with the risk of developing colorectal cancer and other studies showed high total oxidant status ( TOS) are involved in the occurrence and development of malignant tumors. This study aims to investigate the change in the levels of calcium, vitamin D and total oxidant status levels in colorectal Patients. The results showed significance increased in total oxidant status in colorectal cancer patients but not for benign tumor and healthy peoples. Calcium levels were within the ideal limits for all groups and had not relationship with colorectal cancer. While vitamin D levels were below the normal level for all groups and Vitamin D levels was lower in the colorectal cancer group. Found inverse relationship between vitamin D levels and total oxidant status. [ABSTRACT FROM AUTHOR]