Challenges of Discrepant HIV Tests in Pregnant Women in the PrEP era-to Treat or Not to Treat?

<bold>Background: </bold>During HIV retesting in antenatal and preexposure prophylaxis (PrEP) care, discrepant results occur, but guidelines are lacking.<bold>Methods: </bold>In a Kenyan trial implementing antenatal PrEP, if 1 test is reactive, a second is performed; if discrepant, both are repeated; if persistently discrepant, DNA polymerase chain reaction (PCR) is performed.<bold>Results: </bold>Among 4451 women, 23 265 HIV retesting sessions were performed; 14 (0.06%, 95% confidence interval, 0.03%-0.10%) had discrepant results among 10 individuals; in all 10 initial cases, PCR was negative.<bold>Conclusions: </bold>Discrepant rapid tests are an expected, rare, and important challenge for antenatal care HIV retesting, with and without PrEP.<bold>Clinical Trials Registration: </bold>NCT03070600. [ABSTRACT FROM AUTHOR]