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Association Between Midpregnancy Polyunsaturated Fatty Acid Levels and Offspring Autism Spectrum Disorder in a California Population-Based Case-Control Study.
- Source :
-
American Journal of Epidemiology . Feb2021, Vol. 190 Issue 2, p265-276. 12p. - Publication Year :
- 2021
-
Abstract
- Polyunsaturated fatty acids (PUFAs) are critical for brain development and have been linked with neurodevelopmental outcomes. We conducted a population-based case-control study in California to examine the association between PUFAs measured in midpregnancy serum samples and autism spectrum disorder (ASD) in offspring. ASD cases (n  = 499) were identified through the California Department of Developmental Services and matched to live-birth population controls (n  = 502) on birth month, year (2010 or 2011), and sex. Logistic regression models were used to examine crude and adjusted associations. In secondary analyses, we examined ASD with and without co-occurring intellectual disability (ID; n  = 67 and n = 432, respectively) and effect modification by sex and ethnicity. No clear patterns emerged, though there was a modest inverse association with the top quartile of linoleic acid level (highest quartile vs. lowest: adjusted odds ratio = 0.74, 95% confidence interval: 0.49, 1.11; P for trend = 0.10). Lower levels of total and ω-3 PUFAs were associated with ASD with ID (lowest decile of total PUFAs vs. deciles 4–7: adjusted odds ratio = 2.78, 95% confidence interval: 1.13, 6.82) but not ASD without ID. We did not observe evidence of effect modification by the factors examined. These findings do not suggest a strong association between midpregnancy PUFA levels and ASD. In further work, researchers should consider associations with ASD with ID and in other time windows. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AUTISM risk factors
*CONFIDENCE intervals
*PEOPLE with intellectual disabilities
*PREGNANT women
*RISK assessment
*UNSATURATED fatty acids
*LINOLEIC acid
*LOGISTIC regression analysis
*SECONDARY analysis
*DEMOGRAPHIC characteristics
*CASE-control method
*DESCRIPTIVE statistics
*ODDS ratio
*CHILDREN
*PREGNANCY
Subjects
Details
- Language :
- English
- ISSN :
- 00029262
- Volume :
- 190
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- American Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 148481976
- Full Text :
- https://doi.org/10.1093/aje/kwaa171