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Galectin-9 as a biomarker of disease severity.
- Source :
-
Cellular Immunology . Mar2021, Vol. 361, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- • Galectin-9 is known for its immunomodulatory role in innate and adaptive immunity. • Plasma levels of Galectin-9 are elevated in various pathophysiological conditions. • Galectin-9 levels correlate positively with parameters of disease severity. • Galectin-9 is a potentially reliable, sensitive and non-invasive biomarker. Galectin-9 (Gal-9) is a β-galactoside binding lectin known for its immunomodulatory role in various microbial infections. Gal-9 is expressed in all organ systems and localized in the nucleus, cell surface, cytoplasm and the extracellular matrix. It mediates host-pathogen interactions and regulates cell signalling via binding to its receptors. Gal-9 is involved in many physiological functions such as cell growth, differentiation, adhesion, communication and death. However, recent studies have emphasized on the elevated levels of Gal-9 in autoimmune disorders, viral infections, parasitic invasion, cancer, acute liver failure, atopic dermatitis, chronic kidney disease, type-2 diabetes, coronary artery disease, atherosclerosis and benign infertility-related gynecological disorders. In this paper we have reviewed the potential of Gal-9 as a reliable, sensitive and non-invasive biomarker of disease severity. Tracking changes in Gal-9 levels and its implementation as a biomarker in clinical practice will be an important tool to monitor disease activity and facilitate personalized treatment decisions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00088749
- Volume :
- 361
- Database :
- Academic Search Index
- Journal :
- Cellular Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 148475147
- Full Text :
- https://doi.org/10.1016/j.cellimm.2021.104287