Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids.

The article discusses glucocorticoids (GC), synthesized by the 11-hydroxylase (Cyp11b1), control excessive inflammation for immunosuppressive actions. Topics include the skin has proposed to regulate homeostasis by autonomous GC production in keratinocytes; and in line with 11-hydroxylase deficiency in human inflammatory skin disorders, genetic in vivo Cyp11b1 ablation and long-term GC deficiency in keratinocytes primed the murine skin immune system.