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Corticospinal tract involvement in spinocerebellar ataxia type 3: a diffusion tensor imaging study.

Authors :
Inada, Bruno Shigueo Yonekura
Rezende, Thiago Junqueira Ribeiro
Pereira, Fernando Vieira
Garcia, Lucas Ávila Lessa
da Rocha, Antônio José
Neto, Pedro Braga
Barsottini, Orlando Graziani Povoas
França Jr, Marcondes Cavalcante
Pedroso, José Luiz
Source :
Neuroradiology. 2021, Vol. 63 Issue 2, p217-224. 8p.
Publication Year :
2021

Abstract

Purpose: The aim of this study was to evaluate the integrity of the corticospinal tracts (CST) in patients with SCA3 and age- and gender-matched healthy control subjects using diffusion tensor imaging (DTI). We also looked at the clinical correlates of such diffusivity abnormalities. Methods: We assessed 2 cohorts from different Brazilian centers: cohort 1 (n = 29) scanned in a 1.5 T magnet and cohort 2 (n = 91) scanned in a 3.0 T magnet. We used Pearson's coefficients to assess the correlation of CST DTI parameters and ataxia severity (expressed by SARA scores). Results: Two different results were obtained. Cohort 1 showed no significant between-group differences in DTI parameters. Cohort 2 showed significant between-group differences in the FA values in the bilateral precentral gyri (p < 0.001), bilateral superior corona radiata (p < 0.001), bilateral posterior limb of the internal capsule (p < 0.001), bilateral cerebral peduncle (p < 0.001), and bilateral basis pontis (p < 0.001). There was moderate correlation between CST diffusivity parameters and SARA scores in cohort 2 (Pearson correlation coefficient: 0.40–0.59). Conclusion: DTI particularly at 3 T is able to uncover and quantify CST damage in SCA3. Moreover, CST microstructural damage may contribute with ataxia severity in the disease. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00283940
Volume :
63
Issue :
2
Database :
Academic Search Index
Journal :
Neuroradiology
Publication Type :
Academic Journal
Accession number :
148390906
Full Text :
https://doi.org/10.1007/s00234-020-02528-3