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Corticospinal tract involvement in spinocerebellar ataxia type 3: a diffusion tensor imaging study.
- Source :
-
Neuroradiology . 2021, Vol. 63 Issue 2, p217-224. 8p. - Publication Year :
- 2021
-
Abstract
- Purpose: The aim of this study was to evaluate the integrity of the corticospinal tracts (CST) in patients with SCA3 and age- and gender-matched healthy control subjects using diffusion tensor imaging (DTI). We also looked at the clinical correlates of such diffusivity abnormalities. Methods: We assessed 2 cohorts from different Brazilian centers: cohort 1 (n = 29) scanned in a 1.5 T magnet and cohort 2 (n = 91) scanned in a 3.0 T magnet. We used Pearson's coefficients to assess the correlation of CST DTI parameters and ataxia severity (expressed by SARA scores). Results: Two different results were obtained. Cohort 1 showed no significant between-group differences in DTI parameters. Cohort 2 showed significant between-group differences in the FA values in the bilateral precentral gyri (p < 0.001), bilateral superior corona radiata (p < 0.001), bilateral posterior limb of the internal capsule (p < 0.001), bilateral cerebral peduncle (p < 0.001), and bilateral basis pontis (p < 0.001). There was moderate correlation between CST diffusivity parameters and SARA scores in cohort 2 (Pearson correlation coefficient: 0.40–0.59). Conclusion: DTI particularly at 3 T is able to uncover and quantify CST damage in SCA3. Moreover, CST microstructural damage may contribute with ataxia severity in the disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00283940
- Volume :
- 63
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Neuroradiology
- Publication Type :
- Academic Journal
- Accession number :
- 148390906
- Full Text :
- https://doi.org/10.1007/s00234-020-02528-3