An Expeditious Ultrasound-Initiated Green Synthesis of 1,2,4-Thiadiazoles in Water.

A convenient, environmentally benign, metal- and catalyst-free protocol has been developed for the conversion of thioamides to the corresponding 1,2,4-thiadiazole derivatives with chloranil under ultrasound irradiation in water at room temperature. This paper describes a general procedure for the synthesis of different 1,2,4-thiadiazoles in excellent yield in short reaction time via sonochemistry. [ABSTRACT FROM AUTHOR]