Pathogenic TLR3 Variant in a Patient with Recurrent Herpes Simplex Virus 1–Triggered Erythema Multiforme.

First, in HSV-associated EM, HSV-1 viral genes are expressed in intralesional keratinocytes and drive T helper 1-mediated inflammatory responses [[9]]. 1:CAS:528:DC%2BC3cXovFels7g%3D. 10.1074/jbc.M109.047464 9 Gober MD, Laing JM, Burnett JW, Aurelian L. The herpes simplex virus gene pol expressed in herpes-associated erythema multiforme lesions upregulates/activates SP1 and inflammatory cytokines. 1:CAS:528:DC%2BD2sXos1Kns7c%3D. 10.1159/000104259 10 Aurelian L, Ono F, Burnett J. Herpes simplex virus (HSV)-associated erythema multiforme (HAEM): a viral disease with an autoimmune component. [Extracted from the article]