Back to Search
Start Over
لاکتوکوکوس نوترکيب :رهيافتي نوين براي دستيابي به واکسن هاي دهاني.
- Source :
-
Arak Medical University Journal . 12/1/2020, Vol. 23 Issue 5, p16-56. 41p. - Publication Year :
- 2020
-
Abstract
- Background and Aim: The genus of Lactococcus lactis belonging to the lactic acid bacteria (LAB) group, is a gram positive, faculative anaerobic, non-spore forming and non-motile bacterium. The aims of this paper are to introduce Lactic acid bacteria especially non-pathogenic, non-invasive and safe Lactococcus lactis, to study the previous studies and to investigate the advantages, limitations, promotion methods and future prospects of oral vaccine based on this bacterium as a promising strategy for vaccine production and prevention of some infectious diseases. Materials and Methods: In this review article, 62 articles related to Lactococcus lactis and its application in producing oral vaccines were collected via data bases such as PubMed, Google Scholar, Scopus since 1981-2020. Findings: Lactococcus lactis, as a safe microorganism (GRAS) widely used in the food industry. Live recombinant Lactococcus lactis as a "biologic drug" is orally administered as one of the live vaccines expressing viral and bacterial antigens. Conclusion: Recombinant Lactococcus-based vector can be suitable substitutes for live attenuated vaccines and can be considered as a safe and food-grade host for producing the desired products of human consumption over other systems. It also has a high potential for vaccine delivery, especially through mucosal methods to prevent or treat certain diseases. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Persian
- ISSN :
- 17355338
- Volume :
- 23
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Arak Medical University Journal
- Publication Type :
- Academic Journal
- Accession number :
- 148323155
- Full Text :
- https://doi.org/10.32598/jams.23.5.5030.3