Overall control herbal medicine in best consistency.

• This paper put forward the standard preparation control mode. • The systematically quantified fingerprint method and markers' content to evaluate the quality consistency of CPLT. • The QAMS was proposed to calculate the markers' contents in CPLT, and compared to the standard curve method, it is accurate. • Correlation of raw materials with preparation and predicting quality intelligently were proposed to avoid inferior product. • The UV full fingerprint dissolution was applied to evaluate the rationality of preparation process. The standard preparation (SP) based on the quantitative fingerprint was proposed to control the quality of compound licorice tablets (CPLTs) in this paper, which is a great way to control the quality consistency nowadays. Here, taking China 145 batches of CPLTs from 9 manufacturers as samples to set up High Performance Liquid Chromatography fingerprints and CPLT-SP, and employing the systematically quantified fingerprint method (SQFM) combined five markers' contents to evaluate their quality. The results showed that all samples were qualified. The quantitative analysis of multi-components by single-marker (QAMS) for the determination of five components in CPLTs was applied, and there was no striking diversity in the results compared to the standard curve method. Furthermore, the correlation between raw materials and preparation of CPLTs was studied for predicting quality intelligently. As well as the ultraviolet full fingerprint dissolution was applied to evaluate the rationality of preparation. The results demonstrated that SQFM based on SP can integrally and perfectly control the quality of HD in best consistency. [ABSTRACT FROM AUTHOR]