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Splicing factors: Insights into their regulatory network in alternative splicing in cancer.

Authors :
Du, Jun-Xian
Zhu, Gui-Qi
Cai, Jia-Liang
Wang, Biao
Luo, Yi-Hong
Chen, Cong
Cai, Cheng-Zhe
Zhang, Si-Jia
Zhou, Jian
Fan, Jia
Zhu, Wei
Dai, Zhi
Source :
Cancer Letters. Mar2021, Vol. 501, p83-104. 22p.
Publication Year :
2021

Abstract

More than 95% of all human genes are alternatively spliced after transcription, which enriches the diversity of proteins and regulates transcript and/or protein levels. The splicing isoforms produced from the same gene can manifest distinctly, even exerting opposite effects. Mounting evidence indicates that the alternative splicing (AS) mechanism is ubiquitous in various cancers and drives the generation and maintenance of various hallmarks of cancer, such as enhanced proliferation, inhibited apoptosis, invasion and metastasis, and angiogenesis. Splicing factors (SFs) play pivotal roles in the recognition of splice sites and the assembly of spliceosomes during AS. In this review, we mainly discuss the similarities and differences of SF domains, the details of SF function in AS, the effect of SF-driven pathological AS on different hallmarks of cancer, and the main drivers of SF expression level and subcellular localization. In addition, we briefly introduce the application prospects of targeted therapeutic strategies, including small-molecule inhibitors, siRNAs and splice-switching oligonucleotides (SSOs), from three perspectives (drivers, SFs and pathological AS). Finally, we share our insights into the potential direction of research on SF-centric AS-related regulatory networks. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03043835
Volume :
501
Database :
Academic Search Index
Journal :
Cancer Letters
Publication Type :
Academic Journal
Accession number :
148308448
Full Text :
https://doi.org/10.1016/j.canlet.2020.11.043