Back to Search
Start Over
Cytokines in Febrile Diseases.
- Source :
-
Journal of Interferon & Cytokine Research . Jan2021, Vol. 41 Issue 1, p1-11. 11p. - Publication Year :
- 2021
-
Abstract
- The human body has a perfect thermoregulatory system to meet the needs of normal life activities. The central regulation of body temperature is mainly explained by the theory of "setting point (setpoint, SP)". Fever is a positive but nonspecific response of the body to infections and other pyrogens, which causes immune cells to release cytokines, leading to a brain protein-mediated rise in body temperature. Cytokines can be roughly divided into 2 categories: proinflammatory cytokines and anti-inflammatory cytokines. IL-1, TNF-α, and IL-6 are proinflammatory cytokines, whereas IL-4 and IL-10 are anti-inflammatory cytokines. IL-2 is a cytokine that can both activate and inhibit immunity. IL-8 is a neutrophil chemotactic factor, and IFN is a cytokine that plays a key role in the proper induction and maintenance of innate and acquired immunity. This article reviews the pathophysiological characteristics of fever and the cytokines related to fever (IL-2, 4, 6, 8, 10, IFN, TNF, etc.). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10799907
- Volume :
- 41
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Interferon & Cytokine Research
- Publication Type :
- Academic Journal
- Accession number :
- 148204879
- Full Text :
- https://doi.org/10.1089/jir.2020.0213