天麻钩藤饮联合醒脑开窍针刺法对急性脑梗死患者血管内皮功能、 脑血管储备功能及 CD62P、CD63 表达的影响.

Objective: To explore the effect of tianma gouteng decoction combined with xingnao kaiqiao needling as auxiliary on vascular endothelial function, cerebrovascular reserve function and alpha-granular membrane protein (CD62P), lysosome intact membrane protein (CD63) of patients with acute cerebral infarction. Methods: 80 cases of patients with acute cerebral infarction in our hospital from 2017 January to December 2019 were selected. According to the random indicator method, they were divided into the control group (n=40, treated with conventional treatment) and the observation group (n=40, treated with tianma gouteng decoction combined with xingnao kaiqiao needling as auxiliary on the basis of conventional treatment). The clinical efficient, United States national institutes of health stroke scale (NIHSS) score, hasegawa intelligence scale (HDS) score, Barthel index, endothelial function indexes [including nitric oxide (NO), endothelin 1 (ET-1)], cerebrovascular reserve function indexes [cerebrovascular reserve (CVR), pulse index (PI)] and the levels of platelet CD62P and CD63 of two groups before and after treatment were compared. Results: Total effective rate of observation group was 92.50% (37/40), which was significantly higher than the control group [70.00% (28/40)], and the difference was statistically significant (P<0.05). NIHSS score of the observation group after treatment was significantly lower than that in the control group, while HDS score and Barthel index were significantly higher than that in the control group (P<0.05). The levels of serum NO and CVR after treatment in the observation group were significantly higher than those in the control group, and the expression levels of serum ET-1, PI and platelet CD62P and CD63 were significantly lower than those in the control group (P<0.05). Conclusion: On the basis of conventional treatment, tianma gouteng decoction combined with xingnao kaiqiao needling as auxiliary has a significant clinical effect in the treatment of acute cerebral infarction, which can significantly improve vascular endothelial function, cerebrovascular reserve function and nerve function, improve the quality of life, and improve the expression of platelet CD62P and CD63. [ABSTRACT FROM AUTHOR]