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Effects of infliximab on brain neurochemistry of adults with bipolar depression.
- Source :
-
Journal of Affective Disorders . Feb2021, Vol. 281, p61-66. 6p. - Publication Year :
- 2021
-
Abstract
- <bold>Objectives: </bold>To explore the relationship between inflammation and neuronal metabolism in bipolar disorder (BD) by evaluating the neurochemical effects of the tumor necrosis factor-α (TNF-α) antagonist infliximab among individuals with bipolar depression METHODS: This is a post-hoc, exploratory analysis from a 12-week, randomized, double-blind, placebo-controlled trial with infliximab for adults with bipolar depression. We assessed the effects of infliximab on concentration of metabolites in the prefrontal cortex, using proton-magnetic resonance spectroscopy (1H-MRS), as well as its association with clinical outcomes (i.e. depressive symptom severity and cognitive function).<bold>Results: </bold>Eighteen participants in the placebo and 15 in the infliximab group were included in this analysis. In the pre-specified primary outcome, there were no significant effects of treatment on prefrontal concentrations of N-acetylaspartate (NAA; p = 0.712). In the secondary analyses, there was a significant treatment by time interaction for glutamate (Glx; p = 0.018), indicating that Glx levels decreased in infliximab-treated patients, relative to placebo. Treatment group significantly moderated the association between changes in Glx levels and changes in a neurocognitive test (i.e. Digit Symbol Substitution Test; p = 0.014), indicating that in infliximab-treated participants reductions in Glx were associated with cognitive improvement.<bold>Conclusions: </bold>Treatment with infliximab did not affect prefrontal NAA concentration in adults with BD. Exploratory analysis suggested a potential effect of treatment on the glutamate system, a finding that should be confirmed and validated by additional studies. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIPOLAR disorder
*PROTON magnetic resonance spectroscopy
*INFLIXIMAB
*NEUROCHEMISTRY
*NUCLEAR magnetic resonance spectroscopy
*ADULTS
*BIOCHEMISTRY
*BRAIN
*GLUTAMIC acid
*FRONTAL lobe
*RESEARCH
*RESEARCH methodology
*MEDICAL cooperation
*EVALUATION research
*COMPARATIVE studies
*RESEARCH funding
*ASPARTIC acid
Subjects
Details
- Language :
- English
- ISSN :
- 01650327
- Volume :
- 281
- Database :
- Academic Search Index
- Journal :
- Journal of Affective Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 148185938
- Full Text :
- https://doi.org/10.1016/j.jad.2020.11.128