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Isolation and complete genome analysis of a novel duck picornavirus in China.
- Source :
-
Veterinary Microbiology . Feb2021, Vol. 253, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- • A novel duck picornavirus was isolated from cherry valley ducks with SBDS. • This virus possesses a DHAV-like genome organization except for 2A gene. • This virus may be a member of a novel species in the genus Avihepatovirus. A novel duck picornavirus, designated as duck/AH15/CHN/2015, was isolated and identified from Cherry Valley ducks with short beak and dwarfism syndrome in 2015 in Anhui province of China. Duck/AH15/CHN/2015 has the highest degree of amino acid sequence identity (approximately 43 %) with duck hepatitis A viruses (DHAV) Complete genome analysis revealed that duck/AH15/CHN/2015 possesses a typical picornavirus-like genomic organization, 5' UTR-L-P1 (VP0-VP3-VP1)-P2 (2A1-2A2- 2B-2C)-P3 (3A-3B-3C-3D)-3'UTR-poly (A). The 5'UTR contains a potential type IV internal ribosome entry site, while a conserved "barbell"-like structure is found at the 3'UTR, which is similar to DHAV. Compared to the closest related DHAVs, two unrelated 2A proteins were predicted in duck/AH15/CHN/2015, while three unrelated 2A proteins were presented in DHAVs. Based on the amino acid identity comparison and phylogenetic analysis of P1, 2C, and 3CD (3C and 3D), duck/AH15/CHN/2015 was closely related to but distinct from DHAVs, and it was proposed to be a member of a novel species in the genus Avihepatovirus of the family Picornaviridae. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMINO acid sequence
*DUCK plague
*GENOMES
*HEPATITIS viruses
*BARBELLS
Subjects
Details
- Language :
- English
- ISSN :
- 03781135
- Volume :
- 253
- Database :
- Academic Search Index
- Journal :
- Veterinary Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 148166130
- Full Text :
- https://doi.org/10.1016/j.vetmic.2020.108950