Lack of effect of topical statins in linear porokeratosis.

A treatment regimen with an ointment containing simvastatin 2% and 5% cholesterol was offered to the patients. Areas treated with simvastatin/cholesterol ointment are encircled in white, and the CO2 laser-treated area in Case 2 is marked circled in blue. gl In Case 1, there was only minor improvement after 1 month use of the simvastatin/cholesterol ointment (Fig. An excellent response to topical therapy of four congenital hemidysplasia with ichthyosiform erythroderma and limb defects syndrome patients with an increased concentration of simvastatin ointment. [Extracted from the article]