Synthesis of 5-Chloroisoxazoles Derived from 2,2-Dichlorovinyl Ketones.

The reactions of 2,2-dichlorovinyl ketones with hydroxylamine hydrochloride give the corresponding oximes. The subsequent heterocyclization of the latter under the action of t-BuOK in t-BuOH results in selective formation of 5-chloro-3-alkyl- or 5-chloro-3-aryl-substituted isoxazoles in good yields. [ABSTRACT FROM AUTHOR]