Recent Trends in Enzyme Inhibition and Activation in Drug Design.

It is known that enzymes are involved in many pathological conditions, such as inflammation, diabetes, microbial infections, HIV, neoplastic, neglected diseases and others. In the drug design process, the design of potent enzyme inhibitors is a crucial step in the long way of drug development. Finally, the prediction of the interaction of drug-like compounds with multiple targets for HIV-1 treatment using a ligand-based drug design approach was presented. Alvaxanthone was found to be strong TS inhibitor as the anthelminthic drug demonstrating also antiproliferative activity in tumor cells. [Extracted from the article]