血清 MMP-9, TIMP-1, TNF-琢 及 IL-10 在未足月胎膜早破 而早产产妇中的表达及临床意义.

Objective: To study the expression and clinical significance of serum matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), tumor necrosis factor -琢 (TNF-琢) and interleukin-10 (IL-10) in premature parturients with preterm premature rupture of membranes. Methods: 58 cases of premature parturients with preterm premature rupture of membranes who were treated in our hospital from May 2016 to September 2017 were selected as the study group, 58 full-term parturients who underwent cesarean section in our hospital in the same period were selected as control group in addition. The serum levels of MMP-9, TIMP-1, TNF-琢 and IL-10 were compared between the two groups, the study group were divided into subgroup with chorioamnionitis (n=30) and subgroup without chorioamnionitis(n=28) according to the results of fetal membrane and placenta pathology, the serum levels of MMP-9, TIMP-1, TNF-琢 and IL-10 in both subgroups were compared. Pregnancy outcomes in the study group and control group were recorded. Results: The levels of serum MMP-9 and TNF-琢 in the study group were higher than those of the control group, while the level of TIMP-1 and IL-10 were lower than that of the control group (All P<0.05). The serum levels of MMP-9 and TNF-琢 in subgroup with chorioamnionitis were higher than those of subgroup without chorioamnionitis, the TIMP-1 and IL-10 level was lower than that of subgroup without chorioamnionitis (All P<0.05). The incidence of cesarean section, postpartum hemorrhage, neonatal pneumonia in the study group were all higher than those in the control group, the Apgar score of newborn was lower than that of the control group (All P<0.05). Results: Abnormal elevation of serum MMP-9 and TNF-琢 in premature parturients with preterm premature rupture of membranes, TIMP-1 and IL-10 are abnormal drop, detect TIMP-1, MMP-9, TNF-琢, IL-10 and TIMP-1 in maternal serum are beneficial to the diagnosis of premature rupture of membranes leading to premature delivery and it can clarify the maternal infection status. [ABSTRACT FROM AUTHOR]