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A biodegradable antibacterial alginate/carboxymethyl chitosan/Kangfuxin sponges for promoting blood coagulation and full-thickness wound healing.
- Source :
-
International Journal of Biological Macromolecules . Jan2021, Vol. 167, p182-192. 11p. - Publication Year :
- 2021
-
Abstract
- Conventional wound-dressing materials with structural and functional deficiencies are not effective in promoting wound healing. The development of multifunctional wound dressings is emerging as a promising strategy to accelerate blood coagulation, inhibit bacterial infection, and trigger full-thickness wound into a regenerative process. Herein, multifunctional composite sponges were developed by incorporation of traditional Chinese medicine Kangfuxin (KFX) into alginate (AG)/carboxymethyl chitosan (CMC) via green crosslinking, electrostatic interaction, and freeze-drying methods. It is demonstrated that the AG/CMC/KFX (ACK) sponges exhibit a highly interconnected and porous structure, suitable water vapor transmittance, excellent elastic properties, antibacterial behavior, cytocompatibility, and rapid hemostasis. Further, in a rat full-thickness wounds model, the ACK sponge containing 10% KFX (ACK-10) significantly facilitates wound closure compared to the AC group and ACK sponge containing 5% and 15% KFX. Thus, the multifunctional ACK-10 composite sponge has great promise for the application of full-thickness wound healing. Unlabelled Image • Multifunctional alginate/carboxymethyl chitosan/kangfuxin sponges (ACK) were successfully fabricated. • ACK possessed a highly porous structure and excellent elastic properties. • ACK accelerated hemostasis and inhibited bacterial infection • ACK triggered the full-thickness wound into a regenerative process. [ABSTRACT FROM AUTHOR]
- Subjects :
- *WOUND healing
*BLOOD coagulation
*ALGINIC acid
*CHITOSAN
*CHINESE medicine
Subjects
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 167
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 147992797
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2020.11.168