Immunology & Cell Biology's Top 10 original research articles 2019–2020.

Moving from newborns to naïve T cells, Sood I et al i .4 ask the question, "Are all naïve T cells equal?" The articles by Li I et al i .9 and Obeidy I et al i .8 also center on T-cell function, but this time on two factors that enable cytotoxic T-cell (CTL) effector function: dendritic cell (DC) subsets and actin-related protein 2/3 (Arp2/3). Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes. [Extracted from the article]