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RMRP, RMST, FTX and IPW: novel potential long non-coding RNAs in medullary thyroid cancer.
- Source :
-
Orphanet Journal of Rare Diseases . 1/6/2021, Vol. 16 Issue 1, p1-7. 7p. - Publication Year :
- 2021
-
Abstract
- The relevant role of long non-coding RNAs (lncRNAs) in cancer is currently a matter of increasing interest. Medullary thyroid cancer (MTC) is a rare neuroendocrine tumor (2-5% of all thyroid cancer) derived from the parafollicular C-cells which secrete calcitonin. About 75% of all medullary thyroid cancers are believed to be sporadic medullary thyroid cancer (sMTC), whereas the remaining 25% correspond to inherited cancer syndromes known as Multiple Endocrine Neoplasia type 2 (MEN2). MEN2 syndrome, with autosomal dominant inheritance is caused by germline gain of function mutations in RET proto-oncogene. To date no lncRNA has been associated to MEN2 syndrome and only two articles have been published relating long non-coding RNA (lncRNA) to MTC: the first one linked MALAT1 with sMTC and, in the other, our group determined some new lncRNAs in a small group of sMTC cases in fresh tissue (RMST, FTX, IPW, PRNCR1, ADAMTS9-AS2 and RMRP). The aim of the current study is to validate such novel lncRNAs previously described by our group by using a larger cohort of patients, in order to discern their potential role in the disease. Here we have tested three up-regulated (RMST, FTX, IPW) and one down-regulated (RMRP) lncRNAs in our samples (formalin fixed paraffin embedded tissues from twenty-one MEN2 and ten sMTC patients) by RT-qPCR analysis. The preliminary results reinforce the potential role of RMST, FTX, IPW and RMRP in the pathogenesis of MTC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MEDULLARY thyroid carcinoma
*LINCRNA
*CALCITONIN
*GAIN-of-function mutations
*NEUROENDOCRINE tumors
*THYROID cancer
*PROTEINS
*RESEARCH
*CANCER cells
*THYROID gland tumors
*RESEARCH methodology
*RNA
*MEDICAL cooperation
*EVALUATION research
*SIPPLE syndrome
*COMPARATIVE studies
*RESEARCH funding
Subjects
Details
- Language :
- English
- ISSN :
- 17501172
- Volume :
- 16
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Orphanet Journal of Rare Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 147948522
- Full Text :
- https://doi.org/10.1186/s13023-020-01665-5