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Association of Age With 10-Year Outcomes After Coronary Surgery in the Arterial Revascularization Trial.
- Source :
-
Journal of the American College of Cardiology (JACC) . Jan2021, Vol. 77 Issue 1, p18-26. 9p. - Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>The association of age with the outcomes of bilateral internal thoracic arteries (BITAs) versus single internal thoracic arteries (SITAs) for coronary bypass grafting (CABG) remains to be determined.<bold>Objectives: </bold>The purpose of this study was to evaluate the association between age and BITA versus SITA outcomes in the Arterial Revascularization Trial.<bold>Methods: </bold>The primary endpoints were all-cause mortality and a composite of major adverse events, including all-cause mortality, myocardial infarction, or stroke. Secondary endpoints were bleeding complications and sternal wound complications up to 6 months after surgery. Multivariable fractional polynomials analysis and log-rank tests were used.<bold>Results: </bold>Age did not affect any of the explored outcomes in the overall BITA versus SITA comparison in the intention-to-treat analysis and in the analysis based on the number of arterial grafts received. However, when the intention-to-treat analysis was restricted to the populations of patients between age 50 and 70 years, younger patients in the BITA arm had a significantly lower incidence of major adverse events (p = 0.03).<bold>Conclusions: </bold>Our results suggest that BITA may improve long-term outcome in younger patients, although more randomized data are needed to confirm this hypothesis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTERNAL thoracic artery
*REVASCULARIZATION (Surgery)
*CEREBRAL revascularization
*CORONARY artery bypass
*ARTERIAL grafts
*MYOCARDIAL infarction
*RESEARCH
*CLINICAL trials
*STROKE
*AGE distribution
*RESEARCH methodology
*MEDICAL cooperation
*EVALUATION research
*COMPARATIVE studies
*RANDOMIZED controlled trials
*RESEARCH funding
*HEMORRHAGE
Subjects
Details
- Language :
- English
- ISSN :
- 07351097
- Volume :
- 77
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of the American College of Cardiology (JACC)
- Publication Type :
- Academic Journal
- Accession number :
- 147928901
- Full Text :
- https://doi.org/10.1016/j.jacc.2020.10.047