Back to Search
Start Over
Deletions and duplications of 42 Y chromosomal short tandem repeats in Chinese Han population.
- Source :
-
International Journal of Legal Medicine . 2021, Vol. 135 Issue 1, p153-159. 7p. - Publication Year :
- 2021
-
Abstract
- Genotypes of 42 Y chromosome STR (Y-STR) loci were analyzed for a sample of 1420 unrelated males and 1160 father-son pairs from a Chinese Han population. Deletions of Y-STR loci were detected at DYS389I, DYS389II, DYS437, DYS446, DYS447, DYS448, and DYS557 loci. The most common deletion occurred at DYS448 and DYS557 with a frequency of 0.0056 and 0.0035, respectively. On the other hand, duplications of alleles were observed at DYF387S1a/b, DYS385a/b, DYS460, DYS527a/b, DYS459a/b, and DYS557 loci. The DYF387S1a/b, DYS527a/b, and DYS385a/b showed the highest duplicated frequencies of 0.0148, 0.0134, and 0.0099, respectively. The Y-STRs located on palindromes significantly exhibited more deletions or duplications than those non-palindromic loci. Also, duplications were more frequent than deletions. Hence, deletions or duplications of Y-STRs related to their positions on the Y chromosome. All the 52 deleted or duplicated events occurred in the two-generation families inherited stably. Furthermore, the deletions may show the Chinese Han population specificity, but the duplications may not have a similar phenomenon. Our results will be helpful to correct interpretation of the genetic profile of Y-STR loci in forensic casework. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MICROSATELLITE repeats
*CHINESE people
*SHORT tandem repeat analysis
*Y chromosome
Subjects
Details
- Language :
- English
- ISSN :
- 09379827
- Volume :
- 135
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- International Journal of Legal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 147908534
- Full Text :
- https://doi.org/10.1007/s00414-020-02320-1