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Pulmonary Arterial Enlargement in Well-Treated Persons With Human Immunodeficiency Virus.
- Source :
-
Journal of Infectious Diseases . Jan2021, Vol. 223 Issue 1, p94-100. 7p. - Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>Pulmonary artery enlargement is a marker of pulmonary hypertension. We aimed to determine the proportion with pulmonary artery enlargement among well-treated persons with human immunodeficiency virus HIV (PWH) and uninfected controls.<bold>Methods: </bold>PWH with a chest computed tomography were included from the ongoing Copenhagen Comorbidity in HIV Infection (COCOMO) study. Age and sex-matched uninfected controls were recruited from the Copenhagen General Population Study. Pulmonary artery enlargement was defined as a ratio of >1 between the diameter of the main pulmonary artery (at the level of its bifurcation) and the diameter of the ascending aorta.<bold>Results: </bold>In total, 900 PWH were included, and 44 (5%) had a pulmonary artery-aorta ratio (PA:A) >1. After adjustment for age, sex, and body mass index, obesity (adjusted odds ratio, 4.33; 95% confidence interval, 1.76-10.65; P = .001) and injection drug use (IDU) (4.90; 1.00-18.46; P = .03) were associated with higher odds of having a PA:A >1, and pulmonary indices and smoking status were not. HIV seropositivity was borderline associated with a PA:A >1 (adjusted odds ratio, 1.89; 95% confidence interval, .92-3.85; P = .08).<bold>Conclusions: </bold>A PA:A >1 was common in PWH. Obesity and IDU were independently associated with this finding and HIV serostatus was borderline associated with it, but HIV-related factors were not. Increased awareness may be appropriate in obese PWH and those with IDU. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV
*HIV infections
*PULMONARY artery
*HIV seroconversion
*HIV status
*HIV infection epidemiology
*PULMONARY hypertension diagnosis
*OBESITY
*RESEARCH
*PULMONARY hypertension
*INTRAVENOUS drug abuse
*RESEARCH methodology
*CASE-control method
*MEDICAL cooperation
*EVALUATION research
*COMPARATIVE studies
*AORTA
*COMPUTED tomography
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 223
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 147908239
- Full Text :
- https://doi.org/10.1093/infdis/jiaa339