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Cognate CD4+ T cell licensing of dendritic cells in CD8+ T cell immunity.
- Source :
-
Nature Immunology . Nov2004, Vol. 5 Issue 11, p1143-1148. 6p. - Publication Year :
- 2004
-
Abstract
- Several studies have indicated that CD8+ T cells require CD4+ T cell help for memory formation. Evidence suggests that such help can be antigen independent, challenging whether the 'licensing' of dendritic cells (DCs) by CD4+ T cells is ever required for cytotoxic T lymphocyte (CTL) responses. We show here that help is essential for the generation of CTL immunity to herpes simplex virus 1 and that CD4+ T cells mediate help in a cognate, antigen-specific way. We provide direct in vivo evidence for DC licensing by helper T cells and show that licensing is rapid and essential for the formation of effector and memory CTLs. In situations in which DCs are poorly licensed by pathogen-derived signals, our findings suggest that CTL immunity may be heavily dependent on cognate DC licensing. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DENDRITIC cells
*CD4 antigen
*CD antigens
*T cells
*CELLULAR immunity
*LYMPHOCYTES
Subjects
Details
- Language :
- English
- ISSN :
- 15292908
- Volume :
- 5
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Nature Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14775405
- Full Text :
- https://doi.org/10.1038/ni1129