Oxcarbazepine: Various congenital anomalies: case report.

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A full term female neonate developed Joubert syndrome, large atrial septal defect, Dandy-Walker malformation, a soft tissue mass on the floor of the mouth and epiglottic aplasia following in-utero exposure of oxcarbazepine. Bedside flexible fiberoptic nasolaryngoscopy showed gross abnormalities including absent epiglottis and hypertrophic arytenoids with diminutive interarytenoid area. It was manifested as breathing abnormalities, midbrain and hindbrain abnormalities, developmental delay, hypotonia, syndactyly, polydactyly and atypical eye movements in the neonate. [Extracted from the article]