Granulomas and Guidelines: The Search for Tuberculosis During Tumor Necrosis Factor–α Inhibition.

The article discusses that 4000 persons die of tuberculosis (TB) disease. It mentions the impact of tumor necrosis factor-alpha (TNF)-α inhibitors in increasing the risk and susceptibility of TB infection is well-documented in adults. It also mentions that TNF-α appears essential for the control of primary TB infection and as a defense against reactivation.