The impact of Sample Handling Time on metformin serum concentration.

• The gap between blood sample taking and its centrifugation can have a potential impact on the metformin concentration result. • Two hours gap between taking blood and centrifugation has no impact on the metformin serum concentration. • Although the LC/MS method was used, our findings can be extended to all types of techniques dedicated to assessing metformin concentration. This is an informative article which can help research providers to arrange and conduct studies dedicated to the assessment of metformin serum concentrations. If there is a problem with coordination of sample preparation and it is necessary to measure metformin concentration, two hours gap between blood drain and centrifugation has no impact on the results. [ABSTRACT FROM AUTHOR]