Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD.

The article presents a study which showed that late endosomes promote actin-cytoskeleton remodeling through cytosolic translocation of immature protease cathepsin D (cathD) during microglia migration. Late endosomes are a type of prelysosomal organelles. Also cited are the identification of cathD as a key lysosomal molecule, and its role in the activity of actin-severing protein cofilin to maintain globular-actin (G-actin) monomers.