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Clinical Characteristics and Outcomes of 905 COVID-19 Patients Admitted to Imam Khomeini Hospital Complex in the Capital City of Tehran, Iran.
- Source :
-
Archives of Iranian Medicine (AIM) . Nov2020, Vol. 23 Issue 11, p766-775. 10p. - Publication Year :
- 2020
-
Abstract
- Background: We studied the clinical characteristics and outcomes of 905 hospitalized coronavirus disease 2019 (COVID-19) patients admitted to Imam Khomeini Hospital Complex (IKHC), Tehran, Iran. Methods: COVID-19 patients were recruited based on clinical symptoms and patterns of computed tomography (CT) imaging between February 20 and March 19. All patients were tested for the presence of COVID-19 RNA. The Poisson regression model estimated the incidence rate ratio (IRR) for different parameters. Results: The average age (± standard deviation) was 56.9 (±15.7) years and 61.77% were male. The most common symptoms were fever (93.59%), dry cough (79.78%), and dyspnea (75.69%). Only 43.76% of patients were positive for the RT-PCR COVID-19 test. Prevalence of lymphopenia was 42.9% and more than 90% had elevated lactate dehydrogenase (LDH) or C-reactive protein (CRP). About 11% were severe cases, and 13.7% died in the hospital. The median length of stay (LOS) was 3 days. We found higher risks of mortality in patients who were older than 70 years (IRR = 11.77, 95% CI 3.63--38.18), underwent mechanical ventilation (IRR = 7.36, 95% CI 5.06--10.7), were admitted to the intensive care unit (ICU) (IRR = 5.47, 95% CI 4.00--8.38), tested positive on the COVID-19 test (IRR = 2.80, 95% CI 1.64--3.55), and reported a history of comorbidity (IRR = 1.76, 95% CI 1.07--2.89) compared to their corresponding reference groups. Hydroxychloroquine therapy was not associated with mortality in our study. Conclusion: Older age, experiencing a severe form of the disease, and having a comorbidity were the most important prognostic factors for COVID-19 infection. Larger studies are needed to perform further subgroup analyses and verify high-risk groups. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AGE distribution
*ARTIFICIAL respiration
*C-reactive protein
*COMPUTED tomography
*CONFIDENCE intervals
*DEATH
*LENGTH of stay in hospitals
*HOSPITALS
*HOSPITAL admission & discharge
*INTENSIVE care units
*LACTATE dehydrogenase
*PATIENTS
*REGRESSION analysis
*RNA
*COMORBIDITY
*SYMPTOMS
*TREATMENT effectiveness
*DISEASE incidence
*SEVERITY of illness index
*DESCRIPTIVE statistics
*COVID-19
*HYDROXYCHLOROQUINE
Subjects
Details
- Language :
- English
- ISSN :
- 10292977
- Volume :
- 23
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Archives of Iranian Medicine (AIM)
- Publication Type :
- Academic Journal
- Accession number :
- 147561704
- Full Text :
- https://doi.org/10.34172/aim.2020.102