Web of Science 数据库近5 年股骨头坏死文献计量学及可视化分析.

BACKGROUND: Studies have indicated that femoral head necrosis is a refractory disease in orthopedics. To explore the research status and research focus in the field of osteonecrosis of the femoral head is beneficial to grasp the research direction, promote the development of the field of femoral head necrosis, and make it better serve the clinical practice. OBJECTIVE: To explore the development of research hotspots on osteonecrosis of the femoral head in the past 5 years and predict the future research focus in this field, and to provide reference for relevant researchers. METHODS: Base on the Science Citation Index Extended database of the Web of Science database, we search for literature on osteonecrosis of the femoral head from 2016 to 2020 with the theme of "osteonecrosis of the femoral head,” and the VOSviewer software was applied for visualization analysis, including keyword co-occurrence analysis, co-author analysis, institutional co-authoring analysis, country co-authoring analysis, and co-citation analysis. RESULTS AND CONCLUSION: Based on keyword co-occurrence analysis, current research on osteonecrosis of the femoral head is divided into four main categories: risk factors, diagnose and treatment, orthormorphia, cell biology, genetics heredity of osteonecrosis of the femoral head. Steriod-induced osteonecrosis of the femoral head, bone marrow mesenchymal stem cells, and osteogenic differentiation are recent research hotspots in the field of osteonecrosis of the femoral head. However, the pathogenesis and treatment methods of steroid-induced osteonecrosis of the femoral head have not yet been clarified, and the mechanism of action and therapeutic effects of mesenchymal stem cells are still unclear. Therefore, it is speculated that further excavation of the mechanism of femoral head necrosis and improvement of its treatment are important research contents in the future. To conclude, the mechanism of steroid-induced osteonecrosis of the femoral head and the therapy of bone marrow mesenchymal stem cells for osteonecrosis of the femoral head will be studied deeply around the process of osteogenic differentiation. [ABSTRACT FROM AUTHOR]