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Toll-like receptor mediated lysozyme expression in Niemann-pick disease, type C1.

Authors :
Cougnoux, Antony
Yerger, Julia C.
Fellmeth, Mason
Serra-Vinardell, Jenny
Wassif, Christopher A.
Cawley, Niamh X.
Porter, Forbes D.
Source :
Molecular Genetics & Metabolism. Nov2020, Vol. 131 Issue 3, p364-366. 3p.
Publication Year :
2020

Abstract

Niemann-Pick type C1 (NPC1) is a rare neurodegenerative disease. In NPC1 mouse cerebella, the antibacterial enzyme, lysozyme (Lyz2), is significantly increased in multiple cell types. Due to its possible role in toxic fibril deposition, we confirmed Lyz2 overexpression in culture in different control and NPC1 cell types including human NPC1 fibroblasts. Lyz2 expression is induced by Toll-like receptors potentially in response to lipid storage but does not play a functional role in NPC disease pathology. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10967192
Volume :
131
Issue :
3
Database :
Academic Search Index
Journal :
Molecular Genetics & Metabolism
Publication Type :
Academic Journal
Accession number :
147505365
Full Text :
https://doi.org/10.1016/j.ymgme.2020.10.009