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Michael Adducts of Levoglucosenone with α-Ethoxycarbonyl- and α-Nitrocyclododecanones: Transformation into Chiral Macrolides.
- Source :
-
Chemistry of Heterocyclic Compounds . 2020, Vol. 56 Issue 11, p1434-1439. 6p. - Publication Year :
- 2020
-
Abstract
- Levoglucosenone reacted with α-ethoxycarbonyl- and α-nitrocyclododecanones, leading to the formation of diastereomeric Michael adducts in high yields. Methods were developed for the denitration of the respective nitroadducts by treatment with Raney nickel and Bu3SnH, allowing to optimize the synthesis of a 16-membered chiral macrolide. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MACROLIDE antibiotics
*NICKEL (Coin)
Subjects
Details
- Language :
- English
- ISSN :
- 00093122
- Volume :
- 56
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Chemistry of Heterocyclic Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 147387921
- Full Text :
- https://doi.org/10.1007/s10593-020-02834-x