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Genetic Carriers and Genomic Distribution of cadA6 —A Novel Variant of a Cadmium Resistance Determinant Identified in Listeria spp.

Authors :
Chmielowska, Cora
Korsak, Dorota
Szmulkowska, Barbara
Krop, Alicja
Lipka, Kinga
Krupińska, Martyna
Bartosik, Dariusz
Source :
International Journal of Molecular Sciences. 11/15/2020, Vol. 21 Issue 22, p8713. 1p.
Publication Year :
2020

Abstract

Listeria monocytogenes is a pathogen responsible for severe cases of food poisoning. Listeria spp. strains occurring in soil and water environments may serve as a reservoir of resistance determinants for pathogenic L. monocytogenes strains. A large collection of Listeria spp. strains (155) isolated from natural, agricultural, and urban areas was screened for resistance to heavy metals and metalloids, and the presence of resistance determinants and extrachromosomal replicons. Of the tested strains, 35% were resistant to cadmium and 17% to arsenic. Sequence analysis of resistance plasmids isolated from strains of Listeria seeligeri and Listeria ivanovii, and the chromosome of L. seeligeri strain Sr73, identified a novel variant of the cadAC cadmium resistance efflux system, cadA6, that was functional in L. monocytogenes cells. The cadA6 cassette was detected in four Listeria species, including strains of L. monocytogenes, isolated from various countries and sources—environmental, food-associated, and clinical samples. This resistance cassette is harbored by four novel composite or non-composite transposons, which increases its potential for horizontal transmission. Since some cadAC cassettes may influence virulence and biofilm formation, it is important to monitor their presence in Listeria spp. strains inhabiting different environments. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16616596
Volume :
21
Issue :
22
Database :
Academic Search Index
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
147276390
Full Text :
https://doi.org/10.3390/ijms21228713