Biocomputing and Synthetic Biology in Cells: Cells Special Issue.

Biocomputing and synthetic biology have been two of the most exciting emerging fields in recent years. A gene co-expression network is constructed by using the differentially expressed genes of each cell subpopulation, identified via the use of spectral clustering. Then, in the constructed gene co-expression network, the dense subgraphs are learnt to detect the interactive gene groups. A real cancer scRNA-seq dataset is used for testing the proposed framework to detect interactive gene groups of different cancer subtypes, and results show that different gene co-expression networks and interactive gene groups with different functional enrichment are presented in different subtypes. [Extracted from the article]