P.820Pharmacological inhibition of soluble epoxide hydrolase protects cognitive impairment in a Niemann-Pick mice model.

Niemann-Pick type C (NPC) disease is a childhood autosomal recessive inherited rare neurodegenerative disease characterized by accumulation of cholesterol and glycosphingolipids. Taking into account these mechanisms, we follow a novel approach to deal with NPC disease, by modulating key features of the disease such as inflammation and autophagy, through inhibition of soluble epoxide hydrolase (sEH). Our results suggest that pharmacological inhibition of sEH ameliorate most of the characteristic traits of the NPC in mice, demonstrating that sEH can be considered a potential therapeutic strategy for NPC disease. [Extracted from the article]