Loss of Phosphatase and Tensin Homolog Promotes Cardiomyocyte Proliferation and Cardiac Repair After Myocardial Infarction.

Keywords: cardiomyocyte proliferation; myocardial infarction; PTEN; regeneration EN cardiomyocyte proliferation myocardial infarction PTEN regeneration 2196 2199 4 12/01/20 20201201 NES 201201 The loss of cardiomyocytes after myocardial infarction (MI) in adult mammals leads to heart failure. E, Left, Immunofluorescence staining of EdU incorporation in the MI border region in transverse sections from post-MI 15-week mouse hearts from control and Pten cKO mice. Finally, using the I R26R-Confetti Cre-reporter i lineage tracing system (Figure [R]), we demonstrated that PTEN inhibition by VO-OHpic stimulated cardiomyocyte proliferation in MI-injured adult mouse hearts (Figure [S] and [T]). [Extracted from the article]