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Synthesis and Crystal Structure of Thiazolopyrimidine Derivatives: Insights into Weak Interactions.
- Source :
-
Crystallography Reports . 2020, Vol. 65 Issue 7, p1161-1168. 8p. - Publication Year :
- 2020
-
Abstract
- Thiazolo[3,2-a]pyrimidines namely ethyl 2-acetyl-5-(2-fluorophenyl)-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 3a, ethyl 2-acetyl-5-(3-fluorophenyl)-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 3b, and ethyl 2-acetyl-5-(4-fluorophenyl)-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 3c were obtained by one pot synthesis using substituted 3,4 dihydropyrimidine2-thione (1a–1c) and 3-chloro-2,4-pentanedione in ethanol and characterized by single-crystal X-ray diffraction. The variation in the position of fluorine atom on pyrimidine nucleus and insight into the self-assembly of compounds with varied types of non-covalent interactions has great influence on crystal packing. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CRYSTAL structure
*ATOMIC nucleus
*X-ray diffraction
*INSIGHT
*FLUORINE
Subjects
Details
- Language :
- English
- ISSN :
- 10637745
- Volume :
- 65
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Crystallography Reports
- Publication Type :
- Academic Journal
- Accession number :
- 147199255
- Full Text :
- https://doi.org/10.1134/S1063774520070202