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Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study.
- Source :
-
Journal of Alzheimer's Disease . 2020, Vol. 78 Issue 3, p1245-1257. 13p. - Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>Fluid intelligence (FI) involves abstract problem-solving without prior knowledge. Greater age-related FI decline increases Alzheimer's disease (AD) risk, and recent studies suggest that certain dietary regimens may influence rates of decline. However, it is uncertain how long-term food consumption affects FI among adults with or without familial history of AD (FH) or APOE4 (ɛ4).<bold>Objective: </bold>Observe how the total diet is associated with long-term cognition among mid- to late-life populations at-risk and not-at-risk for AD.<bold>Methods: </bold>Among 1,787 mid-to-late-aged adult UK Biobank participants, 10-year FI trajectories were modeled and regressed onto the total diet based on self-reported intake of 49 whole foods from a Food Frequency Questionnaire (FFQ).<bold>Results: </bold>Daily cheese intake strongly predicted better FIT scores over time (FH-: β= 0.207, p < 0.001; ɛ4-: β= 0.073, p = 0.008; ɛ4+: β= 0.162, p = 0.001). Alcohol of any type daily also appeared beneficial (ɛ4+: β= 0.101, p = 0.022) and red wine was sometimes additionally protective (FH+: β= 0.100, p = 0.014; ɛ4-: β= 0.59, p = 0.039). Consuming lamb weekly was associated with improved outcomes (FH-: β= 0.066, p = 0.008; ɛ4+: β= 0.097, p = 0.044). Among at risk groups, added salt correlated with decreased performance (FH+: β= -0.114, p = 0.004; ɛ4+: β= -0.121, p = 0.009).<bold>Conclusion: </bold>Modifying meal plans may help minimize cognitive decline. We observed that added salt may put at-risk individuals at greater risk, but did not observe similar interactions among FH- and AD- individuals. Observations further suggest in risk status-dependent manners that adding cheese and red wine to the diet daily, and lamb on a weekly basis, may also improve long-term cognitive outcomes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALZHEIMER'S disease
*ANIMAL nutrition
*FLUID intelligence
*RED wines
*FOOD consumption
*SALT
*DISEASE progression
*RESEARCH
*PROBLEM solving
*TISSUE banks
*CHEESE
*RESEARCH methodology
*COGNITION
*MEDICAL cooperation
*EVALUATION research
*COMPARATIVE studies
*APOLIPOPROTEINS
*INTELLECT
*WINES
*MEDICAL history taking
*ALCOHOL drinking
*QUESTIONNAIRES
*RESEARCH funding
*PHENOTYPES
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 13872877
- Volume :
- 78
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Alzheimer's Disease
- Publication Type :
- Academic Journal
- Accession number :
- 147183860
- Full Text :
- https://doi.org/10.3233/JAD-201058