In-depth assessment of new Ti-based biocompatible materials.

The objective of the research is to obtain Ti20Mo x Si (where x = 0, 0.5, 0.75, 1.0 wt %) alloys using the vacuum arc remelting (VAR) methods and to consider the effects of Mo and Si on physical-chemical, biological and mechanical biocompatibility. Through microstructure analysis the dendrites, grains, sub-grains, compounds have been confirmed; Mo adding determined the main β phase apparition and by increasing the Si content the dendritic microstructure was evidenced. The modulus of elasticity decreases with the amount of Si in the Ti20Mo alloys. The MTT assessment and fluorescent microscopy performed on fibroblasts and osteoblasts cells indicated a suitable cytocompatibility of the prepared alloys. Expression of osteopontin, metalloproteinases 2 and 9 (MMP2 and MMP9) in these areas into the periosteum and peri-implant highlight the bone mineralization. Mineralization and bone remodeling suggest a good biocompatibility of the implanted material with human tissue. • Obtaining of new biocompatible Ti20Mo x Si alloys. • Addition of Si improves mechanical properties - low Young modulus and good hardness values. • Albino rabbit fibroblasts and human MG63 osteosarcoma cell line co-incubated with the material do not affect cell growth and morphology. • Expression of osteopontin, metalloproteinases 2 and 9 into the periosteum and peri-implant highlights the bone mineralization. [ABSTRACT FROM AUTHOR]