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Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population
- Source :
-
Cancer Letters . Nov2004, Vol. 215 Issue 2, p191-198. 8p. - Publication Year :
- 2004
-
Abstract
- Studies suggest that IL-1β (encoded by IL-1B gene) is a pro-inflammatory cytokine and potent inhibitor of gastric acid secretion, which is proposed as a key determinant in gastric carcinogenesis. Two potentially functional polymorphisms (C-31T and T-511C) in the IL-1B promoter were suggested to be correlated with alteration of Helicobacter pylori infection and IL-1β expression and therefore may be associated with risk of gastric cancer. To test the hypothesis that these two polymorphisms are associated with gastric cancer risk, we performed a case–control study of 280 histologically confirmed gastric cancer patients and 258 age, sex frequency-matched cancer-free controls in a Chinese population. Multivariate logistic regression analyses revealed that the risks (adjusted odds ratio [OR] and 95% confidence interval [CI]) associated with the IL-1B variant genotypes were 1.64 (95% CI, 1.01–2.66) for -31TT and 1.52 (95% CI, 0.91–2.54) for -511CC, respectively, compared with their wild-type homozygotes. The risks were significantly more evident in individuals with H. pylori infection (adjusted OR, 2.14; 95% CI, 1.13–4.06 for -31TT; adjusted OR, 2.00; 95% CI, 1.02–3.89 for -511CC), which was consistent with the biological effects of IL-1β. When we used the haplotype analyses and assumed the IL-1B -31T and -511C as risk alleles, no synergistic effect was found between these two loci. These findings indicate that these two IL-1B promoter variants may contribute to the risk of developing gastric cancer in the Chinese population, especially in individuals with H. pylori infection. [Copyright &y& Elsevier]
- Subjects :
- *GENES
*CANCER
*REGRESSION analysis
*HYPOTHESIS
Subjects
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 215
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 14717297
- Full Text :
- https://doi.org/10.1016/j.canlet.2004.07.012