Макро- и микроэлементный состав межпозвонковых дисков при грыжах поясничного отдела позвоночника

Studies of the mechanisms of lumbar spine disease are relevant, as the choice of adequate treatment requires in-depth knowledge of the its etiopathogenesis changes in the spine tissues. The macro- and microelement content of intervertebral disc herniation (IDH) are least studied. Objective: to assess changes in the element composition of intervertebral disc herniation at conditions of degree of degeneration. Methods: using instrumental neutron activation analysis (INAA) we studied biomaterial obtained during microdiscectomy at LIII-LIV, LIV-LV, LV-SI spine levels. Group A -- 8 fragments of hernias from patients aged 24-36 years with structural changes of intervertebral discs, group B -- 7 fragments from patients at the age of 37-44 years with total degeneration of the spinal motor segments, group B -- 7 samples from patients aged 45-60 years with degenerative deformities of the spine. INAA allowed to outline the content of 22 essential trace elements. The maximum error of the activation method for determining the elements did not exceed 12%. Results: it was found a gradual change in the content of certain essential elements depending on the stage of the destructive process in intervertebral discs tissues. In particular, changes in sodium, potassium, chlorine leads to contravention of acid-base balance in the tissues, reducing the iron content by 1.44 times -- to reduce the flow of oxygen to the intervertebral disc. At the same time, the reduction of calcium levels at the beginning of the degenerative process by 2 times, and then its increase by 1.6 times indicates on calcification of the intervertebral soft tissues. Conclusions: microelement correlations in intervertebral discs tissues are established and the course of the degenerative process can be used to predict the patient's condition and the choice of adequate treatment. [ABSTRACT FROM AUTHOR]