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Clinical and Neuroimaging Correlates of Post-Transplant Delirium.

Authors :
Smith, Patrick
Thompson, Jillian C.
Perea, Elena
Wasserman, Brian
Bohannon, Lauren
Racioppi, Alessandro
Choi, Taewoong
Gasparetto, Cristina
Horwitz, Mitchell E.
Long, Gwynn
Lopez, Richard
Rizzieri, David A.
Sarantopoulos, Stefanie
Sullivan, Keith M.
Chao, Nelson J.
Sung, Anthony D.
Source :
Biology of Blood & Marrow Transplantation. Dec2020, Vol. 26 Issue 12, p2323-2328. 6p.
Publication Year :
2020

Abstract

• Delirium is common following hematopoietic stem cell transplantation. • In this select sample, greater age, treatment regimen intensity, and greater white matter burden were all associated with greater delirium incidence. Delirium is common among adults undergoing hematopoietic stem cell transplantation (HCT), although the clinical and neuroimaging correlates of post-HCT delirium have not been adequately delineated. We therefore examined the frequency of delirium and neuroimaging correlates of post-transplant delirium in a retrospective cohort of 115 adults undergoing neuroimaging after allogeneic HCT. Delirium was established using previously validated methods for retrospective identification of chart-assessed postprocedural delirium. Chart reviews were independently conducted by a multidisciplinary team with expertise in HCT, psychiatry, and psychology on consecutive allogeneic HCT patients who underwent neuroimaging assessments and transplantation at a single center between January 2009 and December 2016. Neuroimaging markers of white matter damage and brain volume loss were also recorded. In total, 115 patients were included, ranging in age from 20 to 74 years (mean [SD] age, 49 [13]). Fifty-three patients (46%) developed post-HCT delirium. In an adjusted model, delirium incidence was associated with older age (odds ratio [OR], 1.92 [1.28, 2.87] per decade, P =.002), greater severity of white matter hyperintensities (OR, 1.95 [1.06, 3.57], P =.031), and conditioning intensity (OR, 6.37 [2.20, 18.45], P <.001) but was unrelated to cortical atrophy (P =.777). Delirium was associated with fewer hospital-free days (P =.023) but was not associated with overall survival (hazard ratio, 0.95 [0.56, 1.61], P =.844). Greater incidence of delirium following HCT was associated with greater age, microvascular burden, and conditioning intensity. Pre-HCT consideration of microvascular burden and other neuroimaging biomarkers of risk may be warranted. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10838791
Volume :
26
Issue :
12
Database :
Academic Search Index
Journal :
Biology of Blood & Marrow Transplantation
Publication Type :
Academic Journal
Accession number :
147114000
Full Text :
https://doi.org/10.1016/j.bbmt.2020.09.016