Individual and simultaneous voltammetric sensing of norepinephrine and tyramine based on poly(L-arginine)/reduced graphene oxide composite film modified glassy carbon electrode.

This article details a voltammetric sensor for the simultaneous determination of norepinephrine (NE) and tyramine (TYM) using poly (L-arginine) and reduced graphene oxide composite film modified glassy carbon electrode (p (L-Arg)/ERGO/GCE). Under optimized conditions, the sensor displayed well separated and resolved peaks for the electro oxidation of NE and TYM. Quantification of these analytes were achieved with wide linear ranges and low detection limits both individually and simultaneously. The mechanistic parameters have been clearly addressed. The efficacy of the proposed sensor has been proved by the successful application of the method in physiological fluids. • A simple and facile voltammetric sensor based on p(L-arginine)/reduced graphene oxide composite film modified GCE. • Sensor displayed well separated and well resolved peaks for the electro oxidation of Norepinephrine and Tyramine. • Individual and simultaneous determination have been achieved with wide linear ranges and low detection limits. • Reliability of the proposed method has been certified in physiological fluids. [ABSTRACT FROM AUTHOR]