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Emergence of Concurrent Multiple EGFR Mutations and MET Amplification in a Patient With EGFR-Amplified Advanced Gastric Cancer Treated With Cetuximab.
- Source :
-
JCO Precision Oncology . 11/17/2020, Vol. 4, p1407-1413. 7p. - Publication Year :
- 2020
-
Abstract
- Chromosomal instability is one of the characteristics of gastric cancer (GC)[1],[2] associated with frequent amplifications of receptor tyrosine kinase (RTK)-related genes. We present a patient with I EGFR i -amplified GC who acquired substantial numbers of I EGFR i mutations and I MET i amplification during the cetuximab treatment as detected by serial ctDNA sequencing. The number of I EGFR i mutations (range, 1-7; Fig 3C) or known actionable I EGFR i mutations (range, 1-6; Fig 3D) were lower than those seen in our GC patient with 22 I EGFR i mutations, including seven known actionable mutations. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 24734284
- Volume :
- 4
- Database :
- Academic Search Index
- Journal :
- JCO Precision Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 147045813
- Full Text :
- https://doi.org/10.1200/PO.20.00263