The Tyrosine Phosphatase Shp2 Regulates Yapy357 Phosphorylation, And In Vivo Sensitivity To Cytotoxic Chemotherapy In Cholangiocarcinoma.

Herein we explore the role of tyrosine phosphatases in regulating YAP tyrosine phosphorylation and sensitivity to current cytotoxic chemotherapy. B Results: b Profiling of tyrosine phosphatase levels by RT-PCR and immunoblot demonstrated higher levels in KMCH cells compared to HuCCT-1; notably the YAP-interacting phosphatase PTPN11 (SHP2) was elevated. [Extracted from the article]