ID 118. Provision of Standardised All-in-One Parenteral Nutrition for Very Preterm Neonates: Evaluation at Room and Cold Temperatures.

Introduction: The AIO-parenteral nutrition is essential for patient with limited venous access e.g. premature infants. Until now there is still conflicting data related to the stability of all in-one parenteral nutrition. Objectives: The aim of this study is to examine the physical stability and sterility of AIO-PN during being stored at room and cold temperature. Materials and Methods: AIO-PN contains dextrose, amino acid, lipid, sodium chloride, magnesium sulphate, potassium chloride, calcium gluconate and also vitamin. Formulation of AIO-PN is prepared based on guidance of nutrition for preterm baby with weight of 1000g and with three days of age. The formulation of AIO-PN then is stored at room temperature (25.43 °C ± 0.54) and cold temperature (6,2 °C ± 2.04). Results: Based on the experiments, all formulas confidently meet the sterile criteria, where there is no microbial growth in the formula within 7 days. During 7 days, the droplet size of all formulas were under the range (<500nm) with a good range of pH. However, during being stored under room temperature, AIO-PN showed the creaming starting at day 3 and the discoloration starting at day 5. We found that there is no such physical changes of the formula within 7 days under cold temperature. Conclusion: This research confirmed that AIO-PN being stored at room temperature cannot be used starting at the day 3, but the formulation storage under cold temperature remains accepted within 7 days. [ABSTRACT FROM AUTHOR]