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Stationary distribution of a stochastic Alzheimer's disease model.

Authors :
Hu, Jing
Zhang, Qimin
Meyer‐Baese, Anke
Ye, Ming
Source :
Mathematical Methods in the Applied Sciences. 11/30/2020, Vol. 43 Issue 17, p9706-9718. 13p.
Publication Year :
2020

Abstract

In this paper, based on the pathogenesis of Alzheimer's disease, we investigate a stochastic mathematical model, focusing on the dynamics of β‐amyloid (Aβ) plaques, Aβ oligomers, PrPC proteins, and the Aβ‐x‐PrPC complex. Within the framework of the Lyapunov method, we first show existence and uniqueness of global positive solution of the model and then establish the sufficient conditions for existence of an ergodic stationary distribution of the positive solution. Ultimately, numerical examples are presented to illustrate the effectiveness of theoretical results. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01704214
Volume :
43
Issue :
17
Database :
Academic Search Index
Journal :
Mathematical Methods in the Applied Sciences
Publication Type :
Academic Journal
Accession number :
146829957
Full Text :
https://doi.org/10.1002/mma.6642